Templating carbohydrate-functionalised polymer-scaffolded dynamic combinatorial libraries with lectins
نویسندگان
چکیده
منابع مشابه
Templating carbohydrate-functionalised polymer-scaffolded dynamic combinatorial libraries with lectins.
A conceptually new approach to the design of macromolecular receptors for lectins is outlined. Carbohydrate-functionalised Polymer-Scaffolded Dynamic Combinatorial Libraries (PS-DCLs) have been prepared in aqueous solution by the reversible conjugation of carbohydrates possessing acylhydrazide functionalities in their aglycone on to an aldehyde-functionalised polymer scaffold. PS-DCLs have been...
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Dynamic combinatorial chemistry (DCC) has emerged in recent years as a powerful tool for the discovery of molecular receptors. DCC uses reversible covalent reactions to link together building blocks, forming libraries of compounds whose product distributions are under thermodynamic control. The reversible nature of the linkages enables the library members to reconfigure their structures by exch...
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Lectins are cell-binding and agglutinating (glyco)proteins found in a variety of living forms. They will be defined here as homogeneous carbohydrate-binding (glyco)proteins principally of plant (seed) origin but also occurring in invertebrate (and vertebrate?) forms. In recent years, lectins have been employed in studying a wide range of biological phenomena including cell differentiation and m...
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ژورنال
عنوان ژورنال: Organic & Biomolecular Chemistry
سال: 2015
ISSN: 1477-0520,1477-0539
DOI: 10.1039/c4ob02587c